Demineralized Bone Matrix
Demineralized bone matrix (DBM) is decalcified allograft bone with osteoinductive potential. The demineralization process exposes growth factors, such as bone morphogenetic proteins (BMP), trapped by minerals. Growth factors recruit immature cells and stimulate those cells to develop into active bone-forming cells called osteoblasts.
Bone grafting is a surgical procedure that replaces missing bone and provides a scaffold for new bone growth. Bone grafts may be autograft (obtained from the patient’s body), allograft (obtained from a donor), or synthetic.
Benefits of using allograft/synthetic versus autograft include:
- Eliminates the need for a second surgical site
- Reduced pain and loss of function from the second surgical site
- Reduced surgical time
- Reduced risk of infection or bleeding
- Reduced recovery time after surgery
Successful bone grafts have one or more of these three properties:
- Osteoconductive: graft acts as a scaffold for the growth of natural bone
- Osteoinductive: graft contains growth factors that recruit immature cells and stimulate those cells to develop into active bone-forming cells called osteoblasts
- Osteogenic: graft directly provides living cells that contribute to the growth of natural bone